Our expertise
At All G, we specialise in harnessing precision fermentation technology to develop next-generation recombinant proteins. Our team combines deep expertise is strain development, bioprocess optimisation and molecular design, with a current focus on human and dairy proteins for high-value applications.
World leading Innovation and Bio Foundry Centre
Our dedicated Waterloo facility integrates a biofoundry, automated strain development, high-throughput screening and downstream processing. Strategically located in Sydney, Australia, we leverage regional advantages in supply chain connectivity, technical talent and market growth to address global nutritional and industrial needs with precision and efficiency.
We are establishing a sophisticated patent-protected IP portfolio that showcases our innovation in recombinant protein production and its various applications.
Jared K. Raynes, Jitendra Mata, Karyn L. Wilde, John A. Carver, Sharon M. Kelly, Carl Holt, Structure of biomimetic casein micelles: Critical tests of the hydrophobic colloid and multivalent-binding models using recombinant deuterated and phosphorylated β-casein, Journal of Structural Biology: X, Volume 9, 2024, 100096, ISSN 2590-1524
Milk contains high concentrations of amyloidogenic casein proteins and is supersaturated with respect to crystalline calcium phosphates such as apatite. Nevertheless, the mammary gland normally remains unmineralized and free of amyloid. Unlike κ-casein, β- and αS-caseins are highly effective mineral chaperones that prevent ectopic and pathological calcification of the mammary gland.
Milk invariably contains a mixture of two to five different caseins that act on each other as molecular chaperones. Instead of forming amyloid fibrils, several thousand caseins and hundreds of nanoclusters of amorphous calcium phosphate combine to form fuzzy complexes called casein micelles.
Read more...