All G - LFX™ 
bovine lactoferrin package
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Product Specs

The LFX advantage

LFX™ is produced via microbial fermentation rather than extraction from milk. This manufacturing approach enables precise control over protein expression and purification, resulting in:

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Low iron saturation designed to maximise iron-binding capacity and support enhanced functional activity.

High-purity output provides a clean, consistent protein profile.

Matches the structural and functional benefits of bovine lactoferrin.

Higher antioxidant activity as more iron-binding sites are available.

No animal-derived ingredients at any stage of production.

* Compared to native bovine lactoferrin in analytical testing.

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Functional benefits of apo-lactoferrin

Apo-lactoferrin is a naturally occurring milk protein, most concentrated in colostrum with well-established bioactive functions.

Apo-lactoferrin helps regulate how the body absorbs and uses iron by influencing key pathways like hepcidin. Studies show improved haemoglobin outcomes versus ferrous sulphate, with fewer side effects.

Apo-lactoferrin supports immune defence through multiple mechanisms, including antimicrobial peptides and activation of immune cells. Clinical studies show increases in key immune markers and reduced inflammatory responses.

Apo-lactoferrin helps control inflammation by reducing oxidative stress and modulating immune signals. Trials show reductions in inflammatory markers and support for anti-inflammatory pathways in the gut.

Apo-lactoferrin supports gut health by strengthening the intestinal barrier and shaping the microbiome. It inhibits harmful bacteria while promoting beneficial species.

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Applications

Apo-lactoferrin’s unique properties make it valuable across multiple applications:

  • Early life nutrition
  • Women’s health
  • Sports & active nutrition
  • Healthy ageing
  • Personal care

Apo-lactoferrin is one of the most important bioactive proteins found in breast milk, with the highest concentrations naturally present in colostrum. It plays a critical role in early development — supporting gut maturation, barrier function, immune system development, and healthy iron status.

Apo-lactoferrin fortification is associated with improved growth outcomes, beneficial microbiota development, and enhanced feeding tolerance in early life nutrition applications.

Iron deficiency remains one of the most prevalent nutritional challenges affecting women globally. Apo-lactoferrin takes a more intelligent approach to iron support — helping regulate absorption through the body’s natural hepcidin pathway.

Associated with improved haemoglobin and iron status compared to ferrous sulphate, apo-lactoferrin also offers reduced inflammation and greater tolerability. Applicable across prenatal health, menstrual support, and everyday wellbeing.

Intense physical activity places increased demands on iron metabolism, immune resilience, and recovery. Apo-lactoferrin supports post-exercise immune defence while helping reduce oxidative stress through its iron-binding and antioxidant properties.

Particularly relevant for endurance and high-performance applications, apo-lactoferrin offers targeted support for athletes — especially women, where iron deficiency remains common.

Healthy aging depends on maintaining immune resilience and managing chronic low-grade inflammation associated with age-related decline. Apo-lactoferrin supports immune balance and has been associated with reduced inflammatory markers in older adult populations.

With multifunctional benefits spanning immunity, iron regulation, and cellular protection, apo-lactoferrin is increasingly relevant in next-generation healthy aging formulations.

Apo-lactoferrin is a naturally occurring bioactive protein found in skin secretions and saliva, recognised for its antimicrobial, anti-inflammatory, and protective properties.

In skincare applications, apo-lactoferrin has been associated with reductions in inflammatory acne lesions, improved sebum regulation, and support for skin repair and overall skin health. In oral care, evidence indicates benefits across periodontal health — including reductions in pathogenic bacteria, gingival inflammation, and periodontal pocket depth.

Nutrition application context

Frequently asked questions

Bovine lactoferrin is an iron-binding protein naturally found in cow’s milk, particularly in colostrum, and is used in nutrition and health applications.

Lactoferrin is used in infant nutrition, dietary supplements, functional foods, and personal care formulations due to its functional properties.

Lactoferrin can be produced using precision fermentation or extracted from milk, followed by purification to create a consistent, high-quality ingredient.

Traditionally, lactoferrin is sourced from cow’s milk. It can also be produced using precision fermentation, without relying on dairy.

Lactoferrin is added to infant formula to support formulations that aim to more closely reflect the functional profile of proteins found in human milk.

References

  1. Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017 Dec;219:45-52. doi: 10.1016/j.ejogrb.2017.10.003. Epub 2017 Oct 4. PMID: 29059584.
  2. Berthon BS, Williams LM, Williams EJ, Wood LG. Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis. Adv Nutr. 2022 Oct 2;13(5):1799-1819. doi: 10.1093/advances/nmac047. PMID: 35481594; PMCID: PMC9526865.
  3. El Amrousy D, El-Afify D, Elsawy A, Elsheikh M, Donia A, Nassar M. Lactoferrin for iron-deficiency anemia in children with inflammatory bowel disease: a clinical trial. Pediatr Res. 2022 Sep;92(3):762-766. doi: 10.1038/s41390-022-02136-2. Epub 2022 Jun 9. PMID: 35681097; PMCID: PMC9556315.
  4. Christofi MD, Giannakou K, Mpouzika M, Merkouris A, Stylianide MV, Charalambous A. The effectiveness of oral bovine lactoferrin compared to iron supplementation in patients with a low hemoglobin profile: A systematic review and meta-analysis of randomized clinical trials. BMC Nutr. 2024 Jan 30;10(1):20. doi: 10.1186/s40795-023-00818-6. PMID: 38291525; PMCID: PMC10825996.
  5. Berthon BS, Williams EJ, Williams LM, Budden KF, Hiles SA, Bartlett NW, Wood LG. Oral lactoferrin reduces systemic inflammation, enhances anti-viral responses and modulates immune cell profiles: a randomised controlled trial in healthy, older adults. Br J Nutr. 2026 Feb 4:1-15. doi: 10.1017/S000711452610631X. Epub ahead of print. PMID: 41634901.
  6. Blais A. Inflammatory bowel diseases: what lactoferrin can do for us? Explor Med. 2025;6:1001330. https://doi.org/10.37349/emed.2025.1001330
  7. Changhui Zhao, Nan Chen, Tolulope Joshua Ashaolu, Prebiotic and modulatory evidence of lactoferrin on gut health and function, Journal of Functional Foods, Volume 108, 2023, 105741, ISSN 1756-4646, https://pmc.ncbi.nlm.nih.gov/articles/PMC6160582/.
  8. Artym J, Zimecki M, Kruzel ML. Lactoferrin for Prevention and Treatment of Anemia and Inflammation in Pregnant Women: A Comprehensive Review. Biomedicines. 2021 Jul 27;9(8):898. doi: 10.3390/biomedicines9080898. PMID: 34440102; PMCID: PMC8389615.
  9. Manzoni P. Clinical Benefits of Lactoferrin for Infants and Children. J Pediatr. 2016 Jun;173 Suppl:S43-52. doi: 10.1016/j.jpeds.2016.02.075. PMID: 27234411.
  10. Shi X, Liu B, Ye W, Qi X, Xi M, Liu S, Zhu Q, Zheng L, Zhao A. Associations of Lactoferrin-Fortified Formula with Infant Growth and Gut Microbiota: A Real-World Observational Study. Nutrients. 2025 Dec 12;17(24):3896. doi: 10.3390/nu17243896. PMID: 41470843; PMCID: PMC12736245.
  11. Chan H, Chan G, Santos J, Dee K, Co JK. A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. Int J Dermatol. 2017 Jun;56(6):686-690. doi: 10.1111/ijd.13607. Epub 2017 Mar 30. PMID: 28369875.
  12. Takayama Y, Aoki R. Roles of lactoferrin on skin wound healing. Biochem Cell Biol. 2012 Jun;90(3):497-503. doi: 10.1139/o11-054. Epub 2012 Feb 14. PMID: 22332789.
  13. Berlutti F, Pilloni A, Pietropaoli M, Polimeni A, Valenti P. Lactoferrin and oral diseases: current status and perspective in periodontitis. Ann Stomatol (Roma). 2011 Mar;2(3-4):10-8. Epub 2012 Jan 27. PMID: 22545184; PMCID: PMC3314318.
  14. Nakano M, Wakabayashi H, Sugahara H, Odamaki T, Yamauchi K, Abe F, Xiao JZ, Murakami K, Ishikawa K, Hironaka S. Effects of lactoferrin and lactoperoxidase-containing food on the oral microbiota of older individuals. Microbiol Immunol. 2017 Oct;61(10):416-426. doi: 10.1111/1348-0421.12537. PMID: 28881387.
  15. Paesano R, Berlutti F, Pietropaoli M, Pantanella F, Pacifici E, Goolsbee W, Valenti P. Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. Biometals. 2010 Jun;23(3):411-7. doi: 10.1007/s10534-010-9335-z. Epub 2010 Apr 21. PMID: 20407805.
  16. Inoue H, Sakai M, Kaida Y, Kaibara K. Blood lactoferrin release induced by running exercise in normal volunteers: antibacterial activity. Clin Chim Acta. 2004 Mar;341(1-2):165-72. doi: 10.1016/j.cccn.2003.12.001. PMID: 14967173.
  17. Rascón-Cruz Q, Siqueiros-Cendón TS, Siañez-Estrada LI, Villaseñor-Rivera CM, Ángel-Lerma LE, Olivas-Espino JA, León-Flores DB, Espinoza-Sánchez EA, Arévalo-Gallegos S, Iglesias-Figueroa BF. Antioxidant Potential of Lactoferrin and Its Protective Effect on Health: An Overview. Int J Mol Sci. 2024 Dec 26;26(1):125. doi: 10.3390/ijms26010125. PMID: 39795983; PMCID: PMC11719613.

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